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KMID : 0921620150450010001
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Journal of Bacteriology and Virology
2015 Volume.45 No. 1 p.1 ~ p.10
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Roles of Outer Membrane Vesicles (OMVs) in Bacterial Virulence
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Lim Sang-Yong
Yoon Hyun-Jin
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Abstract
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Outer membrane vesicles (OMVs) are ubiquitous membranous structures in all Gram-negative bacteria, including pathogens and non-pathogens. Gram-positive bacteria also release membrane-derived vesicles (MV). Originating from the cell envelope, OMVs are enriched with bacterial antigen molecules that conduct multiple functions as decoys to manipulate the host immune system. Besides, OMVs and their components play diverse roles in nutrient acquisition, biofilm formation, and resistance to antibiotics. Despite the diverse benefits ascribed to OMVs, many questions remain unanswered with regard to OMV biogenesis and cargo selectivity. In this report, we review the advantages of vesiculation in the context of all bacteria and then focus on additional benefits acquired by OMVs in pathogenic bacteria.
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KEYWORD
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Outer membrane vesicle (OMV), Pathogen, Virulence
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